No interaction between BIL and OCs is anticipated. Women included in the clinical trials’ programme were required to use an effective contraceptive method, including OCs, and no interactions were observed.
OCs are metabolised by CYP 450, and this explains many of their drug-drug interactions and the potential risk of an unwanted pregnancy. In addition, OCs inhibit CYP 450, and this might interfere with the metabolism of other drugs.
BIL does not inhibit or induce CYP 450. Furthermore, BIL is not metabolised, and so OCs cannot interfere with their elimination.
