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Rinitis Alergica Local

VAS for assessing the perception of antihistamines use in allergic rhinitis

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Ciprandi G, La Mantia I.

Antihistamines are commonly prescribed for the management of allergic rhinitis and urticaria. The quantification of their consumption is relevant in clinical practice, as their use is usually associated with severe symptoms. In addition, symptomatic use of antihistamines is a useful parameter for evaluating allergen immunotherapy effectiveness. However, the use of a diary for recording the number of tablets is frequently negligenced as patients forget to register the actual quantity of tablets taken.

A visual analogue scale (VAS) measures the patient’s perception of symptom severity, emotions and pain.

This study aimed at measuring the VAS for assessing the patient’s perception about antihistamines use in allergic rhinitis. A total of 103 patients with allergic rhinitis due to Parietaria pollen were retrospectively evaluated. They recorded monthly the number of antihistamine tablets taken during the pollen season.

There was a strong relationship between the number of tablets and the VAS score, which represents a possibility of using VAS to estimate the patient’s perception of antihistamines use in clinical practice.

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Allergic Rhinitis Nasal Mucosa

ARIA masterclass 2018: From guidelines to real-life implementation

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Hellings PW, Seys SF, Marien G, Agache I, Canonica W, Gevaert P, Haahtela T, Klimek L, Mullol J, Pfaar O, Scadding G, Scadding G, Valiulis A, Aria AMD, Bousquet J, Pugin B; ARIA masterclass discussants.

Around 20-30% of the European populations suffer from allergic rhinitis, which affects their social life, sleep and work productivity, indirectly rising the economic burden for society.

The ARIA (allergic rhinitis and its impact on asthma) initiative has been developing guidelines for the treatment of allergic rhinitis and asthma to ensure the highest level of best practices in real-life settings, and has evolved towards integrated care pathways using mobile technology and further to management as the key to provide an active and healthy life to all allergic rhinitis patients.

In September 2018, the first ARIA masterclass was held in Brussels with the following key objectives:

  • To provide unbiased education on the best-practices for allergic rhinitis diagnosis, treatment and follow-up
  • To update clinicians about recent research data in allergic rhinitis and asthma, from clinical trials to real-world evidence
  • To share next generation care pathways for the optimal management of patients with allergic rhinitis and asthma
  • To inform clinicians about change management and its impact on healthcare
  • To support clinicians with the adoption of digital solutions in daily practice.

A recent study showed that allergic rhinitis specialists behave like patients, showing a real disconnection between physician’s prescription and patient’s behavior for allergic rhinitis treatment.

The majority of allergists prescribe medications for the entire pollen season, but the vast majority of patients use their medications on-demand when their symptoms are not well controlled.

The objective of the ARIA masterclass was to anticipate a reconnection between physicians and patients, by promoting a patient-centered approach, with a therapeutic strategy tailored to the patient needs but also to their preferences. The use of integrated care pathways and mobile Apps can facilitate this change in care management. In turn, this would result in better symptoms controls for patients, and a substantial reduction of indirect cost for the society.

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Identifying an effective mobile health application for the self-management of allergic rhinitis and asthma in Australia

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Tan R, Cvetkovski B, Kritikos V, O’Hehir RE, Lourenço O, Bousquet J, Bosnic-Anticevich S.

Up to 40% of the population worldwide is affected by allergic rhinitis, which carries a significant burden on individuals and society. Allergic rhinitis symptoms are often self-managed in the community pharmacy setting, with patients underestimating their symptoms and overestimating their ability for effective self-management. In the current technology world, the use of mobile Apps has become more and more popular and represents a promising tool for management of different conditions.

The objective of this study was to identify an effective App for the management of allergic rhinitis and/or asthma. All English and free of charge mobile health-related Apps from the Australian Apple store and Android Google Play store were included in this study and evaluated regarding three domains: accessibility in both App stores, alignment with theoretical principles of the self-management of allergic rhinitis and/or asthma and usability of the App using a mobile App rating scale.

Of a total of 418 Apps retrieved, 31 were evaluated. Many of the evaluated Apps fall short of the self-management principles and most within the field of allergic rhinitis and asthma only deal with either one or other condition. The MASK-air App achieved the highest mean rank and covered all self-management principles except a doctor appointment reminder, with a high rate of engagement.

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La urticaria crónica (CUR) contribuye a la comprensión y el conocimiento de la enfermedad en la región.

Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region

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Gómez RM, Jares E, Borges MS, Baiardini I, Canonica GW, Passalacqua G, Kaplan A, Latour P, Costa E, Dias G, Lavrut J; SLAAI CUR group.

Chronic urticaria (CU) has a widespread spectrum on causal or exacerbating factors, clinical manifestations, therapeutic response and quality of life affectation. Registries are useful tools in several real-life diagnosis and management approach.We aimed to evaluate the characteristics of CU patients living in Latin America through an original cross-sectional registry with data entered by regional allergologists.

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The Role of Mobile Health Technologies in Allergy Care: an EAACI Position Paper.

The Role of Mobile Health Technologies in Allergy Care: an EAACI Position Paper

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Matricardi PM, (…)

Mobile Health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health-related services, data flow and information, patient self-management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task force to assess the state of the art and future potential of mHealth in allergology.

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Diagnosis and treatment of urticaria in primary care

Diagnosis and treatment of urticaria in primary care

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Kayiran MA, Akdeniz N.

Urticaria, also known as hives among people, is a very common disease characterized by erythematous, edematous, itchy, and transient plaques that involve skin and mucous membranes. It is classified as acute spontaneous urticaria, chronic spontaneous urticaria, chronic inducible urticaria, and episodic chronic urticaria. Many factors such as infections, medicines, food, psychogenic factors, and respiratory allergens are accused of etiology, but sometimes, it is idiopathic. Clinical presentation involves red, swelling, and itchy plaques. The lesions usually resolve spontaneously within 2-3 h without a trace.

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Reproducibility of nasal allergen challenge responses in adults with allergic rhinitis

Reproducibility of nasal allergen challenge responses in adults with allergic rhinitis

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Pantin CT, Southworth T, Wetzel K, Singh D.

Allergic rhinitis is characterized by nasal inflammation that occurs in response to allergen exposure. Reproducibility of nasal secretion cytokine responses and physiological measurements are needed to determine the optimum measurements and power calculations for future studies. A group of investigators have investigated the reproducibility of nasal cytokine measurements, using ready-to-use polyvinyl acetate sponges to collect nasal secretions, and measurements of nasal physiological responses.

This study included twelve participants with allergic rhinitis and no history of respiratory disease, and twelve with asthma and allergic rhinitis. They were submitted to a nasal allergen challenge which was repeated 7-14 days later. Participants had an increase in IL-5, and in cytokines CCL11 and CXCL8 responses post-challenge (all P<0.05). Acoustic rhinometry provided good to excellent reproducibility and rhinomanometry had lower reproducibility with greater variation, with some participants unable to perform the measurement. Multiplex immunoassays provided greater sensitivity for cytokine CCL11 measurements. There were no differences between allergic rhinitis patients with and without asthma.

They concluded that polyvinyl acetate sponges are a practical and reproducible way to sample nasal secretions and acoustic rhinometry is a practical and reproducible method for assessing physiological responses

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Treatment of urticaria: a clinical and mechanistic approach

Treatment of urticaria: a clinical and mechanistic approach

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Kaplan AP.

Urticaria can be divided into three general subtypes. Acute urticaria is defined as urticaria of relatively short duration that can be as brief as a day or two or can last up to 6 weeks. “Physical urticarias or inducible urticarias” consist of cold urticaria, cholinergic urticaria, and dermatographism as the most common, plus solar urticaria, local heat urticaria, aquagenic urticaria, vibratory urticaria/angioedema, and delayed pressure urticaria. The third subtype is chronic spontaneous urticaria (CSU) where the urticaria is present for over a minimum of 6 weeks up to many years.

Antihistamines are effective in about 50% of patients with CSU by interacting with the H1 receptor rendering it unresponsive to histamines. Omalizumab is effective in 65–80% of antihistamine-resistant patients and acts by binding IgE, thereby eliminating IgE directed to an autoantigen, downregulating IgE receptors, so that antireceptor antibodies are blocked, and ultimately leading to unresponsiveness of cutaneous mast cells and basophils. The addition of omalizumab represents a major advance because of its efficacy, easy utility, and favourable side-effect profile. Cyclosporine inhibits not only T cells but also histamine release from basophils and mast cells, has a success rate of about 70%, and is recommended third-line with care directed to potential side effects affecting blood pressure and renal function.

In conclusion, the use of antihistamines in high dosage (at least four times a day) is effective in close to half the patients with chronic spontaneous urticaria. For antihistamine resistance, the use of omalizumab has revolutionized therapy of antihistamine-resistant cases because of its efficacy and excellent side-effect profile. If the response is insufficient, cyclosporine is the next choice. Patients should be monitored regarding any adverse effects on blood pressure or renal function. All these are far safer than extended use of corticosteroid.

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Second generation antihistamines: an update

Second generation antihistamines: an update

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Allergic rhinoconjuntivitis, rhinitis and urticaria are major health problems that affect a sizable portion of the population of all ages, interfering with quality of life and resulting in an important burden for the health system.

First generation antihistamines have major unwanted effects, including sedation, weight gain and anticholinergic effects. Second generation H1-antihistamines (SGAHs) are free from the unacceptable side effects of the first-generation ones and are now preferred by physicians and patients as first line therapies.

SGAHs have a good absorption profile, whenever administered orally, with effective plasma concentrations being reached in most of them within 3 hours after dosing. Their liposolubility permits the crossing of cell membranes, helping their bioavailability.

Regarding their metabolism and elimination, H1-antihistamines bind to transporter plasmatic proteins, with plasma protein binding varying from 60 to 95%. The higher plasma protein binding, the less persistent antihistamine effects. Benzodiazepines may decrease H1-antihistamines plasma concentrations. Macrolides, antifungals and calcium antagonists may increase plasmatic concentrations.

H1-antihistamines are well tolerated for allergic rhinoconjunctivitis at the usual dosage. In respect to urticaria, their efficacy is attributed to their H1-antihistaminic activity on small unmyelinated afferent C-fibers to reduce itching, on axonic reflexes to reduce erythema and on the endothelial cells of the post-capillary venules to reduce extravasion and wheal formation. Most H1-antihistamines appear to have anti-inflammatory effects including the reduction of production of preformed and neoformed mediators, cytokines, chemokines and adherence molecules, inflammatory cell recruitment and inflammation in general.

This article summarizes an update on the clinical pharmacology, mechanisms of action and safety of the second-generation antihistamines.

chrnic spontaneous urticaria

The impact of omalizumab on quality of life and its predictors in patients with chronic spontaneous urticaria: Real-life data

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Salman A, Demir G, Bekiroglu N.

A retrospective cohort study was performed to investigate the impact of omalizumab on quality of life and its predictors in chronic spontaneous urticaria.

Omalizumab is an effective and well-tolerated treatment alternative for people with chronic urticaria, however there aren’t studies that assess omalizumab impact on quality of life.

The response to omalizumab therapy was evaluated in 42 patients using urticaria activity score over 7 days and urticaria control test. The impairment in quality of life was assessed using Dermatology Life Quality Index and Chronic Urticaria and Quality of Life Questionnaire.

All scores improved from baseline to first month, remaining stable at the third month. Complete responders had better improvement rates in all scores in all scores compared to others. Gender, age and angioedema had no significant effect on quality of life.

Better scores at baseline might be a predictor of a better response to omalizumab and therefore, more improvement in quality of life of patients with chronic urticaria.

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ácaros del polvo

Determination of the minimally important difference in a nasal symptom score in house dust mite allergy

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Devillier P, Brüning H, Bergmann KC.

House dust mite (HDM) allergens are responsible for the most prevalent persistent respiratory allergies. Clinical trials in this field often use a four-component nasal symptom score (T4NSS) as a measure of efficacy.

The MID for improvement in the T4NSS is at least -0.90 units in children, adolescents and adults suffering from HDM-induced AR. This value could be rounded up to -1 unit for convenience.

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Urticaria crónica

Systematic reviews of pharmacological and nonpharmacological treatments for patients with chronic urticaria: An umbrella systematic review

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Shi Y, Zhou S, Zheng Q, Huang Y, Hao P, Xu M, Zhang L, Xiao X, Zheng H, Li Y.

A wide range of pharmacological and nonpharmacological interventions for chronic urticaria (CU) have been evaluated in systematic reviews (SRs). We conducted an umbrella review of SRs of the effectiveness and safety of pharmacological and nonpharmacological interventions for CU.

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conjuntivitis

Local allergic conjunctivitis: a phenotype of allergic conjunctivitis.

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Yamana Y, Fukuda K, Ko R, Uchio E.

Local allergic rhinitis (LAR) has been reported in the field of otolaryngology; however, the concept of local allergic conjunctivitis (LAC) has not been widely studied in the ophthalmologic community. We routinely examined total IgE levels in tear fluids (t-tIgE) and antigen-specific IgE levels in serum (s-sIgE) in patients with suspected allergic conjunctivitis, on the basis of Japanese guidelines for allergic conjunctival diseases. There are several cases in which the results of t-tIgE and s-sIgE testing are divergent. We suggest that these divergent cases correspond to LAR in otolaryngology.

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Terapia de sangrado

Bloodletting Therapy for Patients with Chronic Urticaria: A Systematic Review and Meta-Analysis

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Yao Q, Zhang X, Mu Y, Liu Y, An Y, Zhao B.

Many trials have reported that bloodletting therapy is effective when treating chronic urticaria. There are currently no systematic reviews of bloodletting therapy for chronic urticaria.

Bloodletting therapy might be an effective and safe treatment for chronic urticaria, but the evidence is scarce. More high quality trials are needed in the future.

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Rinitis Alergica Local

Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis

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Phothijindakul N, Chusakul S, Aeumjaturapat S, Snidvongs K, Kanjanaumporn J, Ruangritchankul K, Phannaso C.

Nasal eosinophilia on nasal cytology was a good screening tool for diagnosing local allergic rhinitis (LAR) because of its high sensitivity and simplicity of the procedure. Unfortunately, the low specificity of nasal eosinophilia makes the nasal provocation test (NPT) necessary for confirmation of LAR.

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